Biochemistry Model Personal Statement
This is the personal statement of a successful Oxbridge Biochemistry applicant.
Searching for how underlying biochemical mechanisms work showed me the fascinating complexity of the molecular world. I first experienced this through Plasmodium's cunning method of recombining var genes to display different proteins on host erythrocytes and avoid detection from the immune system, instantly enticing me to discover more about the hidden intricacies of life.
Learning about enzyme inhibition in school drew me to investigate the molecular processes governing Sarin inhibition of AChE. The dealkylation of Sarin to create aged AChE revealed the complex underlying mechanism which made the inhibited enzyme so hard to reactivate. I presented my research as a poster at the Tonbridge science conference, enhancing my ability to convey complex ideas clearly. Hearing a talk by Dr. Wallace led me to acknowledge the importance of communication: a vehicle of knowledge and inspiration. The talk showed me how unique ligands are used to physically block Sodium voltage-gated channels in epileptic patients, reducing amplitude of depolarization, drawing on my knowledge of action potentials and introducing me to the complexity of drug research.
Reading "The Epigenetic Revolution" made me aware of how non-coding regions of DNA are vital to gene expression, contradicting my assumption of their "junk" worth. I was most struck by the RNA gene Xist and its ability to envelope and shut down entire chromosomes, a major process which inhibits overexpression of genes to avoid catastrophic effects. I read "A Crack in Creation" to gain a better understanding of CRISPR, the technology that can physically edit DNA to create personalised genomes. I was transfixed by the complexity involved with it, such as tracrRNA and targeting multiple sequences, despite its relatively simple structure, but I crucially also learned about the associated ethical dangers.
It was on a conservation trip to Mexico where I experienced primary research, collecting data on coral bleaching due to climate change. Discovering the molecular causation of this process inspired me to understand how zooxanthellae clades contributed to variable bleaching resistance of corals through thylakoid membrane composition, and presented my research at a science fair. The research showed me that understanding the underlying mechanism of problems is crucial in the search for solutions.
The photosynthesis research behind my coral poster led me to discover the importance of redox reactions for life. I thus explored the reduction of Vanillin for my Extended Essay, which allowed me to build on my basic comprehension of organics and redox. The project also trained me to write and structure a scientific research paper, enhanced my experimental skillset and allowed me to analyse data from an IR spectrometer.
Extension classes allowed me to experimentally explore PCR and gel electrophoresis, which amongst other topics inspired me to participate in subject challenges. I received a Silver award in the Biology Olympiad, Copper in C3L6 and Bronze in the UKMT SMC. My multicultural background enables me to converse easily in French and Spanish, and fluently in Russian. I also demonstrate science practicals to KS2 students, to develop their passion and engagement in scientific enquiry. I passed ABRSM grade 6 piano exams with distinction, and concerts allowed me to develop confidence in performing to large groups. I set up a Volleyball club at school, captaining my team to 2nd position at the UK National Beach Volleyball competition, where I was named MVP. I have also played at A team level in rugby, football, and tennis. I was chosen to be a Senior Prefect, a role involved in organising and helping with various duties around campus. All this has served to develop my leadership, teamwork, and exceptional time management.
The skills gained from my scientific and co-curricular pursuits, especially my teamwork, communication and ardour, will allow me to thrive both individually and in a research team.
